The Licensing and Intellectual Property Department of JINR announces that on 9 September 2019, the Joint Institute for Nuclear Research received a patent for the invention “Method for increasing the frequency of formation of double-strand breaks of DNA in human cells under the action of ionizing radiation under conditions of radio modifiers”. The authors of the work are Krasavin Evgeniy Aleksandrovich, Boreiko Alla Vladimirovna, Kulikova Elena Anatolievna, Bulanova Tatiana Sergeevna, Timoshenko Gennadiy Nikolaevich, Chausov Vladimir Nikolaevich.

The results of this research were included in the report of the President of the Russian Academy of Sciences

JINR staff congratulates the authors on receiving the patent for their invention!

More details about the invention

The invention relates to the field of medicine. Disclosed is a method for increasing the frequency of double-strand DNA stripping in human cells under the action of ionizing radiations in conditions of radio modifiers. As inhibitors of DNA repair before irradiation, a combination of formal preparations 1-β-D-arabinofuranosylcytosine and hydroxyurea.
EFFECT: invention provides higher effectiveness of radiation exposure on tumour cells and reduced local radiation dose.