The JINR Innovation and Intellectual Property Department announces that on 6 September 2024, the Joint Institute for Nuclear Research received a certificate of state registration of the software for predicting radiation damage to nerve cells taking into account a detailed description of the subneuronal target, track structure, and radiolysis mechanism. The authors are Munkhbaatar Batmunkh and Lkhagvaa Bayarchimeg (JINR Laboratory of Radiation Biology).

Congratulations to the authors on receiving the state registration certificate!

“Program for predicting radiation damage to nerve cells, taking into account a detailed description of the subneuronal target, track structure, and radiolysis mechanism”

The program is designed for radiobiological estimation of the harmful effect of various types of ionising radiation on the structures of the central nervous system. The program allows modelling the geometry of nerve cells taking into account the spatial organization of numerous dendritic spines and combining them with the track structure model at the physical and chemical radiation stages. The result of the program is a highly accurate prediction of the absorbed dose and the probability of particles entering various parts of the cell (body, axon, dendrites, spikes) under the influence of a wide range of accelerated particles, from protons to iron, with energies from 10 to 1000 MeV/nucleon. The program allows analysing the patterns of energy transfer acts and free radicals distributed along complex dendritic structures. The program helps compare data on the initial radiobiological processes in hippocampal neuron models, both in silico and simplified. The program outputs data in graphical and tabular form. Computer type: IBM PC-compatible Intel/AMD-based PC; x32/x64; OS: Windows, Linux, macOS.
Programming language: C++ using the Geant4, G4Region, G4-DNA, ROOT, and QT5 software suites
Program size: 5.5 MB